The best candidates for a Hormone Replacement Therapy (HRT) prescription are individuals experiencing significant symptoms caused by low hormone levels, such as women going through menopause or perimenopause who suffer from hot flashes, night sweats, mood changes, or bone loss, as well as men with clinically low testosterone levels that affect energy, mood, or sexual health. It is also suitable for transgender individuals seeking gender-affirming treatment to support physical changes aligned with their gender identity. However, ideal candidates are generally those in good overall health without a history of certain cancers, blood clots, stroke, or severe liver disease, and should be evaluated by a healthcare professional to ensure the benefits outweigh the risks.